Details

Autor(en) / Beteiligte

• Penwell, William F
• Shapiro, Adam B
• Giacobbe, Robert A
• Gu, Rong-Fang
• Gao, Ning
• Thresher, Jason
• McLaughlin, Robert E
• Huband, Michael D
• DeJonge, Boudewijn L M
• Ehmann, David E
• Miller, Alita A

Titel

Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii

Ist Teil von

• Antimicrobial agents and chemotherapy, 2015-03, Vol.59 (3), p.1680-1689

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Sulbactam is a class A β-lactamase inhibitor with intrinsic whole-cell activity against certain bacterial species, including Acinetobacter baumannii. The clinical use of sulbactam for A. baumannii infections is of interest due to increasing multidrug resistance in this pathogen. However, the molecular drivers of its antibacterial activity and resistance determinants have yet to be precisely defined. Here we show that the antibacterial activities of sulbactam vary widely across contemporary A. baumannii clinical isolates and are mediated through inhibition of the penicillin-binding proteins (PBPs) PBP1 and PBP3, with very low frequency of resistance; the rare pbp3 mutants with high levels of resistance to sulbactam are attenuated in fitness. These results support further investigation of the potential clinical utility of sulbactam.