Details

Autor(en) / Beteiligte

• Spira, Adam P
• Chen-Edinboro, Lenis P
• Wu, Mark N
• Yaffe, Kristine

Titel

Impact of sleep on the risk of cognitive decline and dementia

Ist Teil von

• Current opinion in psychiatry, 2014-11, Vol.27 (6), p.478-483

Ort / Verlag

United States: Wolters Kluwer Health | Lippincott Williams & Wilkins

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• PURPOSE OF REVIEWTrouble falling or staying asleep, poor sleep quality, and short or long sleep duration are gaining attention as potential risk factors for cognitive decline and dementia, including Alzheimerʼs disease. Sleep-disordered breathing has also been linked to these outcomes. Here, we review recent observational and experimental studies investigating the effect of poor sleep on cognitive outcomes and Alzheimerʼs disease, and discuss possible mechanisms. RECENT FINDINGSObservational studies with self-report and objective sleep measures (e.g. wrist actigraphy, polysomnography) support links between disturbed sleep and cognitive decline. Several recently published studies demonstrate associations between sleep variables and measures of Alzheimerʼs disease pathology, including cerebrospinal fluid measures of Aβ and PET measures of Aβ deposition. In addition, experimental studies suggest that sleep loss alters cerebrospinal fluid Aβ dynamics, decrements in slow-wave sleep may decrease the clearance of Aβ from the brain, and hypoxemia characteristic of sleep-disordered breathing increases Aβ production. SUMMARYFindings indicate that poor sleep is a risk factor for cognitive decline and Alzheimerʼs disease. Although mechanisms underlying these associations are not yet clear, healthy sleep appears to play an important role in maintaining brain health with age, and may play a key role in Alzheimerʼs disease prevention.