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The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study
Movement disorders, 2015-02, Vol.30 (2), p.278-283
Sharp, Madeleine E.
Caccappolo, Elise
Mejia-Santana, Helen
Tang, Ming-X.
Rosado, Llency
Orbe Reilly, Martha
Ruiz, Diana
Louis, Elan D.
Comella, Cynthia
Nance, Martha
Bressman, Susan
Scott, William K.
Tanner, Caroline
Waters, Cheryl
Fahn, Stanley
Cote, Lucien
Ford, Blair
Rezak, Michael
Novak, Kevin
Friedman, Joseph H.
Pfeiffer, Ronald
Payami, Haydeh
Molho, Eric
Factor, Stuart A.
Nutt, John
Serrano, Carmen
Arroyo, Maritza
Pauciulo, Michael W.
Nichols, William C.
Clark, Lorraine N.
Alcalay, Roy N.
Marder, Karen S.
2015
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Sharp, Madeleine E.
Caccappolo, Elise
Mejia-Santana, Helen
Tang, Ming-X.
Rosado, Llency
Orbe Reilly, Martha
Ruiz, Diana
Louis, Elan D.
Comella, Cynthia
Nance, Martha
Bressman, Susan
Scott, William K.
Tanner, Caroline
Waters, Cheryl
Fahn, Stanley
Cote, Lucien
Ford, Blair
Rezak, Michael
Novak, Kevin
Friedman, Joseph H.
Pfeiffer, Ronald
Payami, Haydeh
Molho, Eric
Factor, Stuart A.
Nutt, John
Serrano, Carmen
Arroyo, Maritza
Pauciulo, Michael W.
Nichols, William C.
Clark, Lorraine N.
Alcalay, Roy N.
Marder, Karen S.
Titel
The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study
Ist Teil von
Movement disorders, 2015-02, Vol.30 (2), p.278-283
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
ABSTRACT Background Few studies have systematically investigated the association between PARKIN genotype and psychiatric co‐morbidities of Parkison's disease (PD). PARKIN‐associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive‐compulsive symptoms (OCS). Methods The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early‐onset PD and 257 asymptomatic first‐degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers. Results Among patients, carriers scored lower than noncarriers in adjusted models (one‐mutation: 13.9 point difference, P = 0.03; two‐mutation: 24.1, P = 0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P = 0.05; two mutations, P = 0.13). Conclusions First, a significant association was found between PARKIN mutation status and obsessive‐compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non‐motor dopamine‐dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype. © 2014 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.26065
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4318772
Format
–
Schlagworte
Adult
,
Age of Onset
,
Aged
,
Female
,
Genetic Predisposition to Disease
,
Genetic Testing
,
Genotype
,
Heterozygote
,
Humans
,
Male
,
Middle Aged
,
Movement disorders
,
Mutation - genetics
,
neuropsychological
,
obsessive-compulsive
,
Obsessive-Compulsive Disorder - etiology
,
Obsessive-Compulsive Disorder - genetics
,
parkin
,
Parkinson Disease - complications
,
Parkinson Disease - genetics
,
Parkinson's
,
Ubiquitin-Protein Ligases - genetics
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