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Profiles of white matter tract pathology in frontotemporal dementia
Human brain mapping, 2014-08, Vol.35 (8), p.4163-4179
Mahoney, Colin J.
Ridgway, Gerard R.
Malone, Ian B.
Downey, Laura E.
Beck, Jonathan
Kinnunen, Kirsi M.
Schmitz, Nicole
Golden, Hannah L.
Rohrer, Jonathan D.
Schott, Jonathan M.
Rossor, Martin N.
Ourselin, Sebastien
Mead, Simon
Fox, Nick C.
Warren, Jason D.
2014
Details
Autor(en) / Beteiligte
Mahoney, Colin J.
Ridgway, Gerard R.
Malone, Ian B.
Downey, Laura E.
Beck, Jonathan
Kinnunen, Kirsi M.
Schmitz, Nicole
Golden, Hannah L.
Rohrer, Jonathan D.
Schott, Jonathan M.
Rossor, Martin N.
Ourselin, Sebastien
Mead, Simon
Fox, Nick C.
Warren, Jason D.
Titel
Profiles of white matter tract pathology in frontotemporal dementia
Ist Teil von
Human brain mapping, 2014-08, Vol.35 (8), p.4163-4179
Ort / Verlag
New York, NY: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Despite considerable interest in improving clinical and neurobiological characterisation of frontotemporal dementia and in defining the role of brain network disintegration in its pathogenesis, information about white matter pathway alterations in frontotemporal dementia remains limited. Here we investigated white matter tract damage using an unbiased, template‐based diffusion tensor imaging (DTI) protocol in a cohort of 27 patients with the behavioral variant of frontotemporal dementia (bvFTD) representing both major genetic and sporadic forms, in relation both to healthy individuals and to patients with Alzheimer's disease. Widespread white matter tract pathology was identified in the bvFTD group compared with both healthy controls and Alzheimer's disease group, with prominent involvement of uncinate fasciculus, cingulum bundle and corpus callosum. Relatively discrete and distinctive white matter profiles were associated with genetic subgroups of bvFTD associated with MAPT and C9ORF72 mutations. Comparing diffusivity metrics, optimal overall separation of the bvFTD group from the healthy control group was signalled using radial diffusivity, whereas optimal overall separation of the bvFTD group from the Alzheimer's disease group was signalled using fractional anisotropy. Comparing white matter changes with regional grey matter atrophy (delineated using voxel based morphometry) in the bvFTD cohort revealed co‐localisation between modalities particularly in the anterior temporal lobe, however white matter changes extended widely beyond the zones of grey matter atrophy. Our findings demonstrate a distributed signature of white matter alterations that is likely to be core to the pathophysiology of bvFTD and further suggest that this signature is modulated by underlying molecular pathologies. Hum Brain Mapp 35:4163–4179, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471
eISSN: 1097-0193
DOI: 10.1002/hbm.22468
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4312919
Format
–
Schlagworte
Alzheimer Disease - diagnosis
,
Alzheimer Disease - pathology
,
Anisotropy
,
Atrophy
,
Biological and medical sciences
,
Brain - pathology
,
C9orf72 Protein
,
Cohort Studies
,
Diffusion Tensor Imaging
,
DTI
,
Female
,
frontotemporal dementia
,
Frontotemporal Dementia - diagnosis
,
Frontotemporal Dementia - genetics
,
Frontotemporal Dementia - pathology
,
Genotyping Techniques
,
Gray Matter - pathology
,
Humans
,
Image Processing, Computer-Assisted
,
Investigative techniques, diagnostic techniques (general aspects)
,
Magnetic Resonance Imaging
,
Male
,
Medical sciences
,
Middle Aged
,
Mutation
,
Nerve Fibers, Myelinated - pathology
,
Nervous system
,
Proteins - genetics
,
Radiodiagnosis. Nmr imagery. Nmr spectrometry
,
Sensitivity and Specificity
,
tau Proteins - genetics
,
tract
,
tractography
,
white matter
,
White Matter - pathology
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