ACS nano, 2015-01, Vol.9 (1), p.251-259
2015
Details
- Autor(en) / Beteiligte
- Titel
- Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles
- Ist Teil von
- ACS nano, 2015-01, Vol.9 (1), p.251-259
- Ort / Verlag
- United States: American Chemical Society
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells. These nanoparticles allow precise control over their formulation, stability in blood serum, and activation of multiple functionalities. Importantly, interferon and pro-inflammatory cytokine activation assays indicate the significantly lower responses for DNA nanoparticles compared to the RNA counterparts, suggesting greater potential of these molecules for therapeutic use.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1936-0851eISSN: 1936-086XDOI: 10.1021/nn504508sTitel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4310632
- Format
- –
- Schlagworte
- Activation, Cellular, Deoxyribonucleic acid, DNA - chemistry, Drug Carriers - chemistry, Fretting, HEK293 Cells, HIV-1 - genetics, Humans, Interference, Models, Molecular, Nanoparticles, Nanoparticles - chemistry, Nanostructure, Nucleic Acid Conformation, Ribonuclease III - metabolism, Ribonucleic acids, RNA - chemistry, RNA Interference, RNA, Small Interfering - chemistry, RNA, Small Interfering - genetics, RNA, Small Interfering - metabolism