Details

Autor(en) / Beteiligte

• Aberle, Denise R
• DeMello, Sarah
• Berg, Christine D
• Black, William C
• Brewer, Brenda
• Church, Timothy R
• Clingan, Kathy L
• Duan, Fenghai
• Fagerstrom, Richard M
• Gareen, Ilana F
• Gatsonis, Constantine A
• Gierada, David S
• Jain, Amanda
• Jones, Gordon C
• Mahon, Irene
• Marcus, Pamela M
• Rathmell, Joshua M
• Sicks, JoRean

Titel

Results of the Two Incidence Screenings in the National Lung Screening Trial

Ist Teil von

• The New England journal of medicine, 2013-09, Vol.369 (10), p.920-931

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• An analysis of the results of this trial, which compared low-dose CT with chest radiography, showed that CT had a lower positive predictive value for a positive screening result but detected more lung cancers at earlier stages. The National Lung Screening Trial (NLST) was a randomized trial of lung-cancer–specific mortality among participants in an asymptomatic high-risk cohort who underwent screening with the use of low-dose helical computed tomography (CT) as compared with screening with the use of single-view posteroanterior chest radiography. The NLST showed a 20% relative reduction in mortality from lung cancer with three rounds of low-dose CT screening (rounds T0, T1, and T2) as compared with radiography. 1 In this article, we present more detailed findings from the two incidence screenings (rounds T1 and T2), including information on rates of positive screening tests, performance characteristics of . . .