Details

Autor(en) / Beteiligte

• Cohen, Daniel T
• Buchwald, Stephen L

Titel

Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media

Ist Teil von

• Organic letters, 2015-01, Vol.17 (2), p.202-205

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)­aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)­aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)­aryl halides and triflates at 2–5 mol % catalyst loadings with temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor.