Details

Autor(en) / Beteiligte

• Espinel-Ingroff, A
• Chowdhary, A
• Gonzalez, G M
• Guinea, J
• Hagen, F
• Meis, J F
• Thompson, 3rd, G R
• Turnidge, J

Titel

Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method

Ist Teil von

• Antimicrobial agents and chemotherapy, 2015-01, Vol.59 (1), p.666-668

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.