Details

Autor(en) / Beteiligte

• Tomas, Nicola M
• Beck, Laurence H
• Meyer-Schwesinger, Catherine
• Seitz-Polski, Barbara
• Ma, Hong
• Zahner, Gunther
• Dolla, Guillaume
• Hoxha, Elion
• Helmchen, Udo
• Dabert-Gay, Anne-Sophie
• Debayle, Delphine
• Merchant, Michael
• Klein, Jon
• Salant, David J
• Stahl, Rolf A.K
• Lambeau, Gérard

Titel

Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy

Ist Teil von

• The New England journal of medicine, 2014-12, Vol.371 (24), p.2277-2287

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2014

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Idiopathic membranous nephropathy is associated with autoantibodies against the phospholipase A2 receptor (PLA2R1) in about 70% of patients. This study identifies another antigen, thrombospondin type-1 domain-containing 7A (THSD7A), which accounts for about 10% of cases. Idiopathic membranous nephropathy is an autoimmune disease and a common cause of the nephrotic syndrome in adults. 1 In 2009, the phospholipase A2 receptor 1 (PLA2R1), a protein that is expressed in glomerular podocytes, was discovered as the major antigen involved in the pathogenesis of adult idiopathic membranous nephropathy. 2 As confirmed by a number of subsequent studies, about 70% of patients with idiopathic membranous nephropathy have circulating autoantibodies against PLA2R1. 2 – 6 The remaining patients, approximately 30% of those with idiopathic membranous nephropathy, have no obvious secondary cause of the disease, and it is thought that other endogenous glomerular antigens may be . . .