International journal of biological sciences, 2015, Vol.11 (1), p.99-108
2015
Details
- Autor(en) / Beteiligte
- Titel
- CEP2 attenuates myoblast differentiation but does not affect proliferation
- Ist Teil von
- International journal of biological sciences, 2015, Vol.11 (1), p.99-108
- Ort / Verlag
- Australia: Ivyspring International Publisher
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- CEP2 (CDC42EP2) is a member of the CDC42 subfamily that belongs to the Rho family. The Rho family plays an important role in a variety of cellular processes including skeletal myogenesis. Here, we find the expression of CEP2 increased significantly during C2C12 myogenesis. Overexpression of CEP2 could attenuate myoblast differentiation, while knockdown of CEP2 by siRNA results in enhancing myogenesis. Furthermore, we demonstrate for the first time that CEP2 attenuates myoblast differentiation via suppression of muscle regulatory factors (MRFs) rather than influencing myoblast proliferation. These results indicate that CEP2 acts as a repressor during myogenesis, which provides new insights into the role of CEP2 in muscle development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1449-2288eISSN: 1449-2288DOI: 10.7150/ijbs.8621Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4278259
- Format
- –
- Schlagworte
- Analysis of Variance, Animals, Blotting, Western, Cell Cycle Proteins - metabolism, Cell Differentiation - physiology, Cell Proliferation - physiology, Fluorescent Antibody Technique, Mice, Muscle Development - physiology, Myoblasts - metabolism, Myoblasts - physiology, Real-Time Polymerase Chain Reaction, Research Paper, Reverse Transcriptase Polymerase Chain Reaction, Rho Guanine Nucleotide Exchange Factors - metabolism