Details

Autor(en) / Beteiligte

• de Paula e Silva, Ana Carolina Alves
• Costa-Orlandi, Caroline Barcelos
• Gullo, Fernanda Patrícia
• Sangalli-Leite, Fernanda
• de Oliveira, Haroldo Cesar
• Silva, Julhiany de Fátima da
• Scorzoni, Liliana
• Pitangui, Nayla de Souza
• Rossi, Suélen Andrea
• Benaducci, Tatiane
• Wolf, Vanessa Gonçalves
• Regasini, Luis Octávio
• Petrônio, Maicon Segalla
• Silva, Dulce Helena Siqueira
• Bolzani, Vanderlan S.
• Fusco-Almeida, Ana Marisa
• Mendes-Giannini, Maria José Soares
• Ríos, José L.
• José L Ríos

Titel

Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi

Ist Teil von

• Evidence-based complementary and alternative medicine, 2014-01, Vol.2014, p.506273-8

Ort / Verlag

United States: Hindawi Publishing Corporation

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14) compound contributed to increase the antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, according to standardized microdilution method described by Clinical Laboratory Standard Institute (CLSI) documents. Moreover this compound has a particularly good selectivity index value, which makes it an excellent candidate for broad-spectrum antifungal prototype and encourages the continuation of subsequent studies for the discovery of its mechanism of action.