Details

Autor(en) / Beteiligte

• Ishida, Takashi
• Tabata, Ryo
• Yamada, Masashi
• Aida, Mitsuhiro
• Mitsumasu, Kanako
• Fujiwara, Masayuki
• Yamaguchi, Katsushi
• Shigenobu, Shuji
• Higuchi, Masayuki
• Tsuji, Hiroyuki
• Shimamoto, Ko
• Hasebe, Mitsuyasu
• Fukuda, Hiroo
• Sawa, Shinichiro

Titel

Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis

Ist Teil von

• EMBO reports, 2014-11, Vol.15 (11), p.1202-1209

Ort / Verlag

London: Blackwell Publishing Ltd

Erscheinungsjahr

2014

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Cell‐to‐cell communication is a fundamental mechanism for coordinating developmental and physiological events in multicellular organisms. Heterotrimeric G proteins are key molecules that transmit extracellular signals; similarly, CLAVATA signaling is a crucial regulator in plant development. Here, we show that Arabidopsis thaliana Gβ mutants exhibit an enlarged stem cell region, which is similar to that of clavata mutants. Our genetic and cell biological analyses suggest that the G protein beta‐subunit1 AGB1 and RPK2, one of the major CLV3 peptide hormone receptors, work synergistically in stem cell homeostasis through their physical interactions. We propose that AGB1 and RPK2 compose a signaling module to facilitate meristem development. Synopsis This study shows that heterotrimeric G proteins modulate stem cell proliferation in the plant shoot apical meristem via CLAVATA signaling pathway and provides evidence that that CLV3 peptide receptor RPK2 is a novel G protein‐coupled receptor. Mutations in the G protein beta‐subunit1 ( agb1 ) lead to an enlarged shoot apical meristem. This phenotype is similar to that of CLAVATA mutants. AGB1 and the CLV3 receptor RPK2 associate and synergistically regulate stem cell homeostasis. Graphical Abstract This study shows that heterotrimeric G proteins modulate stem cell proliferation in the plant shoot apical meristem via CLAVATA signaling pathway and provides evidence that that CLV3 peptide receptor RPK2 is a novel G protein‐coupled receptor.