Neuroscience, 2014-11, Vol.280, p.299-317
2014
Details
- Autor(en) / Beteiligte
- Titel
- Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae
- Ist Teil von
- Neuroscience, 2014-11, Vol.280, p.299-317
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Adult rat CNS endothelial cells express functional TLR4. • The opioid receptor-inactive morphine metabolite M3G activates TLR4-dependent inflammatory signaling in endothelial cells. • Nalmefene is a mu opioid receptor antagonist without TLR4 activity, whereas CTAP is an antagonist at both receptors. • Stimulation of endothelial cells by M3G induces in vivo responses of decreased mechanical thresholds and vasodilation. • The putative glial inhibitors AV1013 and propentofylline also inhibit the inflammatory response of endothelial cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2014.09.020Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4250379
- Format
- –
- Schlagworte
- Analgesics, Animals, Biological and medical sciences, Central Nervous System - drug effects, Central Nervous System - physiology, CTAP, Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors, Cyclic AMP-Dependent Protein Kinases - metabolism, Cyclooxygenase 2 - metabolism, Dinoprostone - secretion, endothelial cell, Endothelial Cells - drug effects, Endothelial Cells - physiology, Fundamental and applied biological sciences. Psychology, Hyperalgesia - drug therapy, Hyperalgesia - physiopathology, M3G, Male, Medical sciences, morphine, Morphine - pharmacology, Morphine Derivatives - pharmacology, nalmefene, Narcotics - pharmacology, Neuroglia - drug effects, Neuroglia - physiology, Neuroimmunomodulation - drug effects, Neuroimmunomodulation - physiology, Neurology, Neuropharmacology, NF-kappa B - metabolism, Pharmacology. Drug treatments, Rats, Sprague-Dawley, Receptors, Opioid, mu - antagonists & inhibitors, Receptors, Opioid, mu - metabolism, RNA, Messenger - metabolism, TLR4, Toll-Like Receptor 4 - agonists, Toll-Like Receptor 4 - metabolism, Tumor Necrosis Factor-alpha - metabolism, Vasodilation - drug effects, Vasodilation - physiology, Vertebrates: nervous system and sense organs