Details

Autor(en) / Beteiligte

• Cetera, Maureen
• Ramirez-San Juan, Guillermina R
• Oakes, Patrick W
• Lewellyn, Lindsay
• Fairchild, Michael J
• Tanentzapf, Guy
• Gardel, Margaret L
• Horne-Badovinac, Sally

Titel

Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation

Ist Teil von

• Nature communications, 2014-11, Vol.5 (1), p.5511-5511, Article 5511

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Tissues use numerous mechanisms to change shape during development. The Drosophila egg chamber is an organ-like structure that elongates to form an elliptical egg. During elongation the follicular epithelial cells undergo a collective migration that causes the egg chamber to rotate within its surrounding basement membrane. Rotation coincides with the formation of a 'molecular corset', in which actin bundles in the epithelium and fibrils in the basement membrane are all aligned perpendicular to the elongation axis. Here we show that rotation plays a critical role in building the actin-based component of the corset. Rotation begins shortly after egg chamber formation and requires lamellipodial protrusions at each follicle cell's leading edge. During early stages, rotation is necessary for tissue-level actin bundle alignment, but it becomes dispensable after the basement membrane is polarized. This work highlights how collective cell migration can be used to build a polarized tissue organization for organ morphogenesis.