Details

Autor(en) / Beteiligte

• McNicholas, Sinead
• Talento, Alida Fe
• O'Gorman, Joanne
• Hannan, Margaret M
• Lynch, Maureen
• Greene, Catherine M
• Humphreys, Hilary
• Fitzgerald-Hughes, Deirdre

Titel

Cytokine responses to Staphylococcus aureusbloodstream infection differ between patient cohorts that have different clinical courses of infection

Ist Teil von

• BMC infectious diseases, 2014-11, Vol.14 (1), Article 580

Ort / Verlag

London: BioMed Central Ltd

Erscheinungsjahr

2014

Link zum Volltext

Quelle

SpringerNature Journals

Beschreibungen/Notizen

• The clinical course of Staphylococcus aureus bloodstream infection is unpredictable and bacterial virulence, host immune response and patient characteristics are among the factors that contribute to the clinical course of infection. To investigate the relationship between cytokine response and clinical outcome, circulating cytokine levels were investigated in response to S. aureus bloodstream infection in patients with different clinical courses of infection. A prospective study was carried out in 61 patients with S. aureus bloodstream infection and circulating levels of IL-6, GRO-[gamma], RANTES and leptin were assessed over the course of the infection. Levels were compared in patients with complicated courses of infection (e.g. infective endocarditis) versus uncomplicated courses of S. aureus bloodstream infection and methicillin-resistant S. aureus Vs methicillin-susceptible S. aureus infection. IL-6 may be an early inflammatory marker of complicated S. aureus bloodstream infection. Leptin may be protective against the development of a complicated S. aureus bloodstream infection.