Molecular brain, 2014-11, Vol.7 (1), p.78-78
2014
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- Autor(en) / Beteiligte
- Titel
- Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning
- Ist Teil von
- Molecular brain, 2014-11, Vol.7 (1), p.78-78
- Ort / Verlag
- England: BioMed Central
- Erscheinungsjahr
- 2014
- Quelle
- AUTH Library subscriptions: Springer Journals
- Beschreibungen/Notizen
- Previous studies have shown that a family of phosphoinositide 3-kinases (PI3Ks) plays pivotal roles in the brain; in particular, we previously reported that knockout of the γ isoform of PI3K (PI3Kγ) in mice impaired synaptic plasticity and reduced behavioral flexibility. To further examine the role of PI3Kγ in synaptic plasticity and hippocampus-dependent behavioral tasks we overexpressed p110γ, the catalytic subunit of PI3Kγ, in the hippocampal CA1 region. We found that the overexpression of p110γ impairs NMDA receptor-dependent long-term depression (LTD) and hippocampus-dependent spatial learning in the Morris water maze (MWM) task. In contrast, long-term potentiation (LTP) and contextual fear memory were not affected by p110γ overexpression. These results, together with the previous knockout study, suggest that a critical level of PI3Kγ in the hippocampus is required for successful induction of LTD and normal learning.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1756-6606eISSN: 1756-6606DOI: 10.1186/s13041-014-0078-6Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4226891
- Format
- –
- Schlagworte
- Animals, Anxiety - physiopathology, CA1 Region, Hippocampal - metabolism, Class I Phosphatidylinositol 3-Kinases - metabolism, HEK293 Cells, Hippocampus - enzymology, Hippocampus - physiopathology, Humans, Long-Term Synaptic Depression, Male, Maze Learning, Mice, Inbred C57BL, Motor Activity, Neuronal Plasticity, p38 Mitogen-Activated Protein Kinases - metabolism, Receptors, N-Methyl-D-Aspartate - metabolism, Spatial Learning, Task Performance and Analysis