The Journal of biological chemistry, 2014-11, Vol.289 (45), p.30880-30888
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter
- Ist Teil von
- The Journal of biological chemistry, 2014-11, Vol.289 (45), p.30880-30888
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2014
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a broader role than simply mediating the ATP-dependent efflux of drugs from cells. The antioxidant GSH and the pro-inflammatory cysteinyl leukotriene C4 have been identified as key physiological organic anions effluxed by MRP1, and an ever growing body of evidence indicates that additional lipid-derived mediators are also substrates of this transporter. As such, MRP1 is a multitasking transporter that likely influences the etiology and progression of a host of human diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9258eISSN: 1083-351XDOI: 10.1074/jbc.R114.609248Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4223294
- Format
- –
- Schlagworte
- Adenosine Triphosphate - chemistry, Animals, Anions, Antioxidants - chemistry, Biological Transport, Cell Line, Tumor, Estrogens - chemistry, Glutathione - chemistry, Humans, Inflammation, Leukotriene C4 - chemistry, Lipids - chemistry, Lysophospholipids - chemistry, Mice, Minireviews, Multidrug Resistance-Associated Proteins - metabolism, Multidrug Resistance-Associated Proteins - physiology, Oxidative Stress, Oxygen - chemistry, Signal Transduction, Xenobiotics - chemistry