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Embryonic origins of the mouse superior olivary complex
Developmental neurobiology (Hoboken, N.J.), 2013-05, Vol.73 (5), p.384-398
Marrs, Glen S.
Morgan, Warren J.
Howell, David M.
Spirou, George A.
Mathers, Peter H.
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Marrs, Glen S.
Morgan, Warren J.
Howell, David M.
Spirou, George A.
Mathers, Peter H.
Titel
Embryonic origins of the mouse superior olivary complex
Ist Teil von
Developmental neurobiology (Hoboken, N.J.), 2013-05, Vol.73 (5), p.384-398
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2013
Quelle
MEDLINE
Beschreibungen/Notizen
Many areas of the central nervous system are organized into clusters of cell groups, with component cell groups exhibiting diverse but related functions. One such cluster, the superior olivary complex (SOC), is located in the ventral auditory brainstem in mammals. The SOC is an obligatory contact point for most projection neurons of the ventral cochlear nucleus and plays central roles in many aspects of monaural and binaural information processing. Despite their important interrelated functions, little is known about the embryonic origins of SOC nuclei, due in part to a paucity of developmental markers to distinguish individual cell groups. In this report, we present a collection of novel markers for the developing SOC nuclei in mice, including the transcription factors FoxP1, MafB, and Sox2, and the lineage‐marking transgenic line En1‐Cre. We use these definitive markers to examine the rhombic lip and rhombomeric origins of SOC nuclei and demonstrate that they can serve to uniquely identify SOC nuclei and subnuclei in newborn pups. The markers are also useful in identifying distinct nuclear domains within the presumptive SOC as early as embryonic day (E) 14.5, well before morphological distinction of individual nuclei is evident. These findings indicate that the mediolateral and dorsoventral position of SOC nuclei characteristic of the adult brainstem is established during early neurogenesis. © 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 384–398, 2013
Sprache
Englisch
Identifikatoren
ISSN: 1932-8451
eISSN: 1932-846X
DOI: 10.1002/dneu.22069
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4217651
Format
–
Schlagworte
Animals
,
auditory brainstem
,
Biomarkers
,
Brain stem
,
Cell Lineage
,
Early Growth Response Protein 2 - analysis
,
Early Growth Response Protein 2 - genetics
,
fate mapping
,
Gene Expression Regulation, Developmental
,
Genes, Reporter
,
Gestational Age
,
Homeodomain Proteins - analysis
,
Homeodomain Proteins - biosynthesis
,
Homeodomain Proteins - genetics
,
Image Processing, Computer-Assisted
,
In Situ Hybridization
,
lineage
,
Mice - embryology
,
Mice, Transgenic
,
Nerve Tissue Proteins - analysis
,
Nerve Tissue Proteins - biosynthesis
,
Nerve Tissue Proteins - genetics
,
Neurogenesis
,
Olivary Nucleus - embryology
,
Recombinant Fusion Proteins - analysis
,
Recombinant Fusion Proteins - genetics
,
Rhombencephalon - embryology
,
rhombomere
,
superior olivary complex
,
Transcription Factors - analysis
,
Transcription Factors - genetics
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