Details

Autor(en) / Beteiligte

• Kaplan, Jonah A
• Lei, Hongyi
• Liu, Rong
• Padera, Robert
• Colson, Yolonda L
• Grinstaff, Mark W

Titel

Imparting Superhydrophobicity to Biodegradable Poly(lactide-co-glycolide) Electrospun Meshes

Ist Teil von

• Biomacromolecules, 2014-07, Vol.15 (7), p.2548-2554

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The synthesis of a family of new poly­(lactic acid-co-glycerol monostearate) (PLA–PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly­(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes. Solutions of PLGA are doped with PLA–PGC18 and electrospun to form meshes with micrometer-sized fibers. Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) properties. Contact angles as high as 160° are obtained with 30% polymer dopant. Lastly, these meshes are nontoxic, as determined by an NIH/3T3 cell biocompatibility assay, and displayed a minimal foreign body response when implanted in mice. In summary, a general method for constructing biodegradable fibrous meshes with tunable hydrophobicity is described for use in tissue engineering and drug delivery applications.