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Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments—The importance of immunofocusing in subunit vaccine design
Vaccine, 2014-10, Vol.32 (46), p.6170-6176
2014

Details

Autor(en) / Beteiligte
Titel
Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments—The importance of immunofocusing in subunit vaccine design
Ist Teil von
  • Vaccine, 2014-10, Vol.32 (46), p.6170-6176
Ort / Verlag
Kidlington: Elsevier Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • Highlights • We express five MERS-CoV RBDs spanning S350-588, 358-588, 367-588, 377-606, and 377-588. • S377-588, 367-588 and 358-588 have the highest receptor binding ability than others. • S377-588 and 367-588 induced the highest-titer of IgG antibodies in mice. • S377-588 elicits highest neutralization in mice and high neutralization in rabbits. • S377-588 contains stably folded RBD structure and major neutralizing epitopes.
Sprache
Englisch
Identifikatoren
ISSN: 0264-410X
eISSN: 1873-2518
DOI: 10.1016/j.vaccine.2014.08.086
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4194190
Format
–
Schlagworte
Allergy and Immunology, Animals, Antibodies, Neutralizing - blood, Antibodies, Viral - blood, Antigens, Viral - immunology, Applied microbiology, Binding sites, Biological and medical sciences, Coronavirus, Coronavirus Infections - prevention & control, Critical neutralizing domain, Female, Fundamental and applied biological sciences. Psychology, Humans, Immunization, Immunofocusing, Immunoglobulin Fc Fragments - immunology, Immunoglobulin G - blood, Infections, Laboratory animals, MERS, MERS-CoV, Mice, Inbred BALB C, Microbiology, Middle East respiratory syndrome, Middle East Respiratory Syndrome Coronavirus, Miscellaneous, Neutralization Tests, Polyclonal antibodies, Rabbits, Receptor-binding domain, Receptors, Virus - metabolism, Respiratory diseases, Spike Glycoprotein, Coronavirus - immunology, Spike protein, Vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects), Vaccines, Subunit - immunology, Viral Vaccines - immunology, Virology

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