Details

Autor(en) / Beteiligte

• Zingg, Brian
• Hintiryan, Houri
• Gou, Lin
• Song, Monica Y.
• Bay, Maxwell
• Bienkowski, Michael S.
• Foster, Nicholas N.
• Yamashita, Seita
• Bowman, Ian
• Toga, Arthur W.
• Dong, Hong-Wei

Titel

Neural Networks of the Mouse Neocortex

Ist Teil von

• Cell, 2014-02, Vol.156 (5), p.1096-1111

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2014

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Numerous studies have examined the neuronal inputs and outputs of many areas within the mammalian cerebral cortex, but how these areas are organized into neural networks that communicate across the entire cortex is unclear. Over 600 labeled neuronal pathways acquired from tracer injections placed across the entire mouse neocortex enabled us to generate a cortical connectivity atlas. A total of 240 intracortical connections were manually reconstructed within a common neuroanatomic framework, forming a cortico-cortical connectivity map that facilitates comparison of connections from different cortical targets. Connectivity matrices were generated to provide an overview of all intracortical connections and subnetwork clusterings. The connectivity matrices and cortical map revealed that the entire cortex is organized into four somatic sensorimotor, two medial, and two lateral subnetworks that display unique topologies and can interact through select cortical areas. Together, these data provide a resource that can be used to further investigate cortical networks and their corresponding functions. [Display omitted] •Imaging database of mouse cortical connectivity•Interactive cortical map allowing direct comparison of cortical projection data•Identification of topologically distinct cortical subnetworks•Insights into the connectivity architecture of the mouse neocortex A comprehensive connectivity atlas of the murine cortex based on injections of neuronal tracers that collectively span the entire neocortex reveals hundreds of neural pathways and specific subnetworks with distinct topologies, providing a rich resource to frame experimental tests of functional connections.