Details

Autor(en) / Beteiligte

• Melero, Ignacio
• Rouzaut, Ana
• Motz, Greg T
• Coukos, George

Titel

T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy

Ist Teil von

• Cancer discovery, 2014-05, Vol.4 (5), p.522-526

Ort / Verlag

United States

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Cancer immunotherapy has great promise, but is limited by diverse mechanisms used by tumors to prevent sustained antitumor immune responses. Tumors disrupt antigen presentation, T/NK-cell activation, and T/NK-cell homing through soluble and cell-surface mediators, the vasculature, and immunosuppressive cells such as myeloid-derived suppressor cells and regulatory T cells. However, many molecular mechanisms preventing the efficacy of antitumor immunity have been identified and can be disrupted by combination immunotherapy. Here, we examine immunosuppressive mechanisms exploited by tumors and provide insights into the therapies under development to overcome them, focusing on lymphocyte traffic.