Details

Autor(en) / Beteiligte

• Hoberman, Alejandro
• Greenfield, Saul P
• Mattoo, Tej K
• Keren, Ron
• Mathews, Ranjiv
• Pohl, Hans G
• Kropp, Bradley P
• Skoog, Steven J
• Nelson, Caleb P
• Moxey-Mims, Marva
• Chesney, Russell W
• Carpenter, Myra A

Titel

Antimicrobial Prophylaxis for Children with Vesicoureteral Reflux

Ist Teil von

• The New England journal of medicine, 2014-06, Vol.370 (25), p.2367-2376

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• In this placebo-controlled trial in children with vesicoureteral reflux after a first or second febrile or symptomatic urinary tract infection, antimicrobial prophylaxis was associated with a substantially reduced risk of recurrence but not of renal scarring. Vesicoureteral reflux is present in one third of children presenting with febrile urinary tract infection and has been associated with a heightened risk of renal scarring. 1 Early randomized, controlled trials that compared antireflux surgery with antimicrobial prophylaxis showed no significant differences in the rates of recurrent urinary tract infection (recurrences) and renal scarring 2 – 5 ; however, the lack of a placebo or observation group precluded a determination that either surgery or prophylaxis was effective. More recent randomized trials, most of which were unblinded, have had conflicting results regarding the effectiveness of antimicrobial prophylaxis in reducing recurrences. 6 – 11 We designed the . . .