Details

Autor(en) / Beteiligte

• Chen, Qianqian
• Zhang, Juan
• Zhao, Kai
• Li, Wei
• Miao, Qi
• Sun, Yang
• Zhao, Xingyu
• Wei, Taotao
• Yang, Fuyu

Titel

Lysosomal chymotrypsin induces mitochondrial fission in apoptotic cells by proteolytic activation of calcineurin

Ist Teil von

• Protein & cell, 2014, Vol.5 (8), p.643-647

Ort / Verlag

Beijing: Higher Education Press

Erscheinungsjahr

2014

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Dear Editor Apoptosis is a fundamental physiological process in mam- mals in which cells die by activating a suicide mechanism. The mitochondria are one of the major checkpoints in apoptotic regulation because they serve as sensors and amplifiers of cellular damage （Green and Kroemer, 2004）. After mitochondrial outer membrane permeabilization （MOMP）, the mitochondria release a number of factors that are critically involved in cell death signaling （Tait and Green, 2010）. Bcl-2 family members are regarded as the key reg- ulators of mitochondria-dependent apoptosis （Moldoveanu et al., 2014）; however, dynamin-related protein 1 （Drpl）, which orchestrates mitochondrial fission, also participates in apoptotic regulation by stimulating Bax oligomerization and thereby enhances MOMP （Montessuit et al., 2010）; accord- ingly, the inhibition of Drpl blocks mitochondrial fission and inhibits apoptosis （Cassidy-Stone et al., 2008）.