Details

Autor(en) / Beteiligte

• Reusser, Nicole M
• Dalton, Heather J
• Pradeep, Sunila
• Gonzalez-Villasana, Vianey
• Jennings, Nicholas B
• Vasquez, Hernan G
• Wen, Yunfei
• Rupaimoole, Rajesh
• Nagaraja, Archana S
• Gharpure, Kshipra
• Miyake, Takahito
• Huang, Jie
• Hu, Wei
• Lopez-Berestein, Gabriel
• Sood, Anil K

Titel

Clodronate inhibits tumor angiogenesis in mouse models of ovarian cancer

Ist Teil von

• Cancer biology & therapy, 2014-08, Vol.15 (8), p.1061-1067

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Purpose Bisphosphonates have been shown to inhibit and deplete macrophages. The effects of bisphosphonates on other cell types in the tumor microenvironment have been insufficiently studied. Here, we sought to determine the effects of bisphosphonates on ovarian cancer angiogenesis and growth via their effect on the microenvironment, including macrophage, endothelial and tumor cell populations. Experimental Design Using in vitro and in vivo models, we examined the effects of clodronate on angiogenesis and macrophage density, and the overall effect of clodronate on tumor size and metastasis. Results Clodronate inhibited the secretion of pro-angiogenic cytokines by endothelial cells and macrophages, and decreased endothelial migration and capillary tube formation. In treated mice, clodronate significantly decreased tumor size, number of tumor nodules, number of tumor-associated macrophages and tumor capillary density. Conclusions Clodronate is a potent inhibitor of tumor angiogenesis. These results highlight clodronate as a potential therapeutic for cancer.