Details

Autor(en) / Beteiligte

• Wada, Naoki
• Singer, Wolfgang
• Gehrking, Tonette L.
• Sletten, David M.
• Schmelzer, James D.
• Kihara, Mikihiro
• Low, Phillip A.

Titel

Determination of vagal baroreflex sensitivity in normal subjects

Ist Teil von

• Muscle & nerve, 2014-10, Vol.50 (4), p.535-540

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• ABSTRACT Introduction: The Valsalva maneuver (VM) is used widely to quantify the sensitivity of the vagal baroreflex loop (vagal baroreflex sensitivity, BRS_v), but most studies have focused on the heart rate (HR) response to blood pressure (BP) decrement (BRS_v↓), even though the subsequent response to an increment in BP after the VM (BRS_v↑) is important and different. Methods: We evaluated recordings of HR and BP in 187 normal subjects during the VM and determined both BRS_v↑, as determined by relating HR to the BP increase after phase III and BRS_v↓. Results: BRS_v↑ was related inversely to age. In addition, BRS_v↓, age, and magnitude of phase IV were independent predictors of BRS_v↑ in a multivariate model, accounting for 47% of the variance of BRS_v↑. Conclusions: The results indicate that both BRS_v↑ and BRS_v↓ become blunted with increasing age and that these indices relate to each other. Muscle Nerve 50: 535–540, 2014