Details

Autor(en) / Beteiligte

• Li, Huifen
• Margolick, Joseph B.
• Bream, Jay H.
• Nilles, Tricia L.
• Langan, Susan
• Bui, Hanhvy T.
• Sylwester, Andrew W.
• Picker, Louis J.
• Leng, Sean X.

Titel

Heterogeneity of CD4⁺ and CD8⁺ T-cell Responses to Cytomegalovirus in HIV-Infected and HIV-Uninfected Men Who Have Sex With Men

Ist Teil von

• The Journal of infectious diseases, 2014-08, Vol.210 (3), p.400-404

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Studies of T-cell immunity to human cytomegalovirus (CMV) primarily reflect anti-CMV pp65 or immediate early antigen 1 (IE-1) activity. We assessed responses of T cells from human immunodeficiency virus (HIV)-negative and HIV-infected men to peptide pools spanning 19 CMV open reading frames selected because they previously correlated with total CMV-specific T-cell responses in healthy donors. Cells producing cytokines in response to pp65 or IE-1 together composed <12% and <40% of the total CD4⁺ and CD8⁺ T-cell responses to CMV, respectively. These proportions were generally similar regardless of HIV serostatus. Thus, analyses of total CMV-specific T-cell responses should extend beyond pp65 and IE-1 regardless of HIV serostatus.