Current opinion in pharmacology, 2014-04, Vol.15, p.7-15
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics
- Ist Teil von
- Current opinion in pharmacology, 2014-04, Vol.15, p.7-15
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Some Kir channels are putative drug targets, but their pharmacology is limited. • Newly discovered inhibitors or activators of Kir2.x, 4.1, and 7.1 are discussed. • Mechanisms of action involve pore-lining residues that control rectification. • This work is a critical first step toward developing more specific modulators.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-4892eISSN: 1471-4973DOI: 10.1016/j.coph.2013.11.002Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4097192
- Format
- –
- Schlagworte
- Animals, Heart Diseases - drug therapy, Heart Diseases - metabolism, Humans, Internal Medicine, Kidney Diseases - drug therapy, Kidney Diseases - metabolism, Medical Education, Models, Molecular, Potassium Channels, Inwardly Rectifying - agonists, Potassium Channels, Inwardly Rectifying - antagonists & inhibitors, Potassium Channels, Inwardly Rectifying - chemistry, Potassium Channels, Inwardly Rectifying - metabolism