Details

Autor(en) / Beteiligte

• Lai, Yen-Chun
• Potoka, Karin C
• Champion, Hunter C
• Mora, Ana L
• Gladwin, Mark T

Titel

Pulmonary Arterial Hypertension: The Clinical Syndrome

Ist Teil von

• Circulation research, 2014-06, Vol.115 (1), p.115-130

Ort / Verlag

United States: American Heart Association, Inc

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Pulmonary arterial hypertension is a progressive disorder in which endothelial dysfunction and vascular remodeling obstruct small pulmonary arteries, resulting in increased pulmonary vascular resistance and pulmonary pressures. This leads to reduced cardiac output, right heart failure, and ultimately death. In this review, we attempt to answer some important questions commonly asked by patients diagnosed with pulmonary arterial hypertension pertaining to the disease, and aim to provide an explanation in terms of classification, diagnosis, pathophysiology, genetic causes, demographics, and prognostic factors. Furthermore, important molecular pathways that are central to the pathogenesis of pulmonary arterial hypertension are reviewed, including nitric oxide, prostacyclin, endothelin-1, reactive oxygen species, and endothelial and smooth muscle proliferation.