Details

Autor(en) / Beteiligte

• McWilliam, Stephen J
• Antoine, Daniel J
• Sabbisetti, Venkata
• Pearce, Robin E
• Jorgensen, Andrea L
• Lin, Yvonne
• Leeder, J Steven
• Bonventre, Joseph V
• Smyth, Rosalind L
• Pirmohamed, Munir

Titel

Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children

Ist Teil von

• Biomarkers in medicine, 2014-12, Vol.8 (10), p.1189-1197

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers of acute kidney injury, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Urinary biomarkers were determined in samples from children in the UK (n = 120) and the USA (n = 171) using both Meso Scale Discovery (MSD) and Luminex-based analytical approaches. 95% reference intervals for each biomarker in each cohort are presented and stratified by sex or ethnicity where necessary, and age-related variability is explored using quantile regression. We identified consistently higher NGAL concentrations in females than males (p < 0.0001), and lower KIM-1 concentrations in African-Americans than Caucasians (p = 0.02). KIM-1 demonstrated diurnal variation, with higher concentrations in the morning (p < 0.001). This is the first report of reference intervals for KIM-1 and NGAL using two analytical methods in a healthy pediatric population in both UK and US-based populations.