Details

Autor(en) / Beteiligte

• Benavente, Oscar R
• Hart, Robert G
• McClure, Leslie A
• Szychowski, Jeffrey M
• Coffey, Christopher S
• Pearce, Lesly A

Titel

Effects of Clopidogrel Added to Aspirin in Patients with Recent Lacunar Stroke

Ist Teil von

• The New England journal of medicine, 2012-08, Vol.367 (9), p.817-825

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• In this randomized trial involving 3020 patients with recent symptomatic lacunar infarcts, the addition of clopidogrel to aspirin did not reduce the risk of recurrent stroke but increased the risk of bleeding. Small subcortical brain infarcts, commonly known as lacunar strokes, constitute about 25% of ischemic strokes 1 – 3 and are particularly frequent among Hispanics. 4 – 9 Although lacunar strokes occasionally result from mechanisms of brain ischemia such as cardiogenic embolism or carotid-artery stenosis, most result from intrinsic disease of the small penetrating arteries. This underlying disorder is the most frequent cause of covert brain infarcts and vascular cognitive impairment. 10 – 12 To our knowledge, the secondary prevention of lacunar stroke as detected by the use of magnetic resonance imaging (MRI) has not been the focus of a randomized trial. Aspirin is accepted as standard . . .