Details

Autor(en) / Beteiligte

• Baragaño Raneros, Aroa
• Suarez Álvarez, Beatriz
• López Larrea, Carlos

Titel

Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention

Ist Teil von

• Oncoimmunology, 2014-04, Vol.3 (4), p.e28497-e28497

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Natural Killer Group 2 member D (NKG2D) activating receptor, present on the surface of various immune cells, plays an important role in activating the anticancer immune response by their interaction with stress-inducible NKG2D ligands (NKG2DL) on transformed cells. However, cancer cells have developed numerous mechanisms to evade the immune system via the downregulation of NKG2DL from the cell surface, including the release of NKG2DL from the cell surface in a soluble form. Here, we review the mechanisms involved in the production of soluble NKG2DL (sNKG2DL) and the potential therapeutic strategies aiming to block the release of these immunosuppressive ligands. Therapeutically enabling the NKG2D-NKG2DL interaction would promote immunorecognition of malignant cells, thus abrogating disease progression.