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Functional and Clinical Significance of Variants Localized to 8q24 in Colon Cancer
Ist Teil von
Cancer epidemiology, biomarkers & prevention, 2009-09, Vol.18 (9), p.2492-2500
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2009
Quelle
MEDLINE
Beschreibungen/Notizen
Multiple genome-wide association studies have identified several susceptibility variants for colon cancer at 8q24. However,
the functional roles of these variants have yet to be elucidated. Here, we evaluated the potential role of these markers in
tumor progression and examined association with commonly observed structural abnormalities in this region, c-MYC amplification and chromosome fragility at FRA8C and FRA8D. We first replicated the previously reported association by testing
1,178 cases and 1,009 clinic-based controls with eight markers localized to three specific regions at 8q24. We observed significant
associations with colon cancer risk with markers rs13254738 (ordinal odds ratio, 0.82; 95% confidence interval, 0.072-0.94;
P trend = 0.0037) and rs6983267 (ordinal odds ratio, 1.17; 95% confidence interval, 1.03-1.32, P trend = 0.013). Survival analysis was done using a separate set of 460 cases to evaluate the clinical significance of these markers.
Overall, univariate analysis did not detect survival differences for any of the markers. We also tested a subset of the 460
cases ( n = 380) for structural abnormalities at or near the c-MYC locus using fluorescence in situ hybridization analysis. Furthermore, we evaluated a small number of cases homozygous for the rs6983267 alleles to test for
differences in fragile site induction. None of the 8q markers correlated with amplification at the c-MYC locus as detected by fluorescence in situ hybridization, and no clear pattern of breakage was observed at the FRA8C and FRA8D sites. In this study, we confirm the
association for several single nucleotide polymorphisms at 8q24 in colon cancer but have not detected any structural role
relating to c-MYC amplification or chromosomal fragility. Finally, these risk alleles do not seem to be associated with survival. (Cancer Epidemiol
Biomarkers Prev 2009;18(9):2492–500)