Details

Autor(en) / Beteiligte

• Morton, Donald L
• Thompson, John F
• Cochran, Alistair J
• Mozzillo, Nicola
• Nieweg, Omgo E
• Roses, Daniel F
• Hoekstra, Harold J
• Karakousis, Constantine P
• Puleo, Christopher A
• Coventry, Brendon J
• Kashani-Sabet, Mohammed
• Smithers, B. Mark
• Paul, Eberhard
• Kraybill, William G
• McKinnon, J. Gregory
• Wang, He-Jing
• Elashoff, Robert
• Faries, Mark B

Titel

Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma

Ist Teil von

• The New England journal of medicine, 2014-02, Vol.370 (7), p.599-609

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2014

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Sentinel-node biopsy followed by lymphadenectomy for tumor-positive nodes improved disease-free survival among patients with intermediate-thickness melanomas (1.2 to 3.5 mm) and those with thick melanomas (>3.5 mm). Regional node management in melanoma has remained controversial since Snow 1 recommended elective complete lymphadenectomy for all patients with melanoma, regardless of whether there was clinical evidence of regional nodal metastases. However, routine elective lymphadenectomy exposes all patients to procedure-related complications and cannot benefit the majority, who have no regional nodal metastases. Multiple randomized trials have suggested a benefit of routine lymphadenectomy in at least some groups of patients with melanoma. 2 – 6 Because of dissatisfaction with both elective lymphadenectomy and nodal observation, lymphatic mapping and sentinel-node biopsy were introduced for individualized management of regional lymph nodes. 6 – 9 Sentinel-node biopsy is a . . .