Details

Autor(en) / Beteiligte

• Vallée, Monique
• Vitiello, Sergio
• Bellocchio, Luigi
• Hébert-Chatelain, Etienne
• Monlezun, Stéphanie
• Martin-Garcia, Elena
• Kasanetz, Fernando
• Baillie, Gemma L.
• Panin, Francesca
• Cathala, Adeline
• Roullot-Lacarrière, Valérie
• Fabre, Sandy
• Hurst, Dow P.
• Lynch, Diane L.
• Shore, Derek M.
• Deroche-Gamonet, Véronique
• Spampanato, Umberto
• Revest, Jean-Michel
• Maldonado, Rafael
• Reggio, Patricia H.
• Ross, Ruth A.
• Marsicano, Giovanni
• Piazza, Pier Vincenzo

Titel

Pregnenolone Can Protect the Brain from Cannabis Intoxication

Ist Teil von

• Science (American Association for the Advancement of Science), 2014-01, Vol.343 (6166), p.94-98

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2014

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), ∆⁹ -tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CBi) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB₁ receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB₁ receptor overactivation that could open an unforeseen approach for the treatment of cannabis intoxication and addiction.