Details

Autor(en) / Beteiligte

• Horng, Tiffany

Titel

Calcuim signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome

Ist Teil von

• Trends in immunology, 2014-03, Vol.35 (6), p.253-261

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to maturation of IL-1β and IL-18 and induction of a pro-inflammatory cell death in sentinel cells of the innate immune system. Diverse stimuli have been shown to activate the NLRP3 inflammasome during infection and metabolic diseases, thus implicating the pathway in triggering both adaptive and maladaptive inflammation in a variety of clinically important settings. Here I discuss the emerging model that signals associated with mitochondrial destabilization may critically activate the NLRP3 inflammasome. Together with studies indicating an important role for Ca 2+ signaling, these findings suggest that many stimuli engage Ca 2+ signaling as an intermediate step to trigger mitochondrial destabilization, thus generating the mitochondria-associated ligands that activate the NLRP3 inflammasome.