Details

Autor(en) / Beteiligte

• Mullin, A P
• Gokhale, A
• Moreno-De-Luca, A
• Sanyal, S
• Waddington, J L
• Faundez, V

Titel

Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes

Ist Teil von

• Translational psychiatry, 2013-12, Vol.3 (12), p.e329-e329

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2013

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Neurodevelopmental disorders such as intellectual disability, autism spectrum disorder and schizophrenia lack precise boundaries in their clinical definitions, epidemiology, genetics and protein-protein interactomes. This calls into question the appropriateness of current categorical disease concepts. Recently, there has been a rising tide to reformulate neurodevelopmental nosological entities from biology upward. To facilitate this developing trend, we propose that identification of unique proteomic signatures that can be strongly associated with patient's risk alleles and proteome-interactome-guided exploration of patient genomes could define biological mechanisms necessary to reformulate disorder definitions.