Details

Autor(en) / Beteiligte

• Rubin, Richard R
• Wadden, Thomas A
• Bahnson, Judy L
• Blackburn, George L
• Brancati, Frederick L
• Bray, George A
• Coday, Mace
• Crow, Scott J
• Curtis, Jeffrey M
• Dutton, Gareth
• Egan, Caitlin
• Evans, Mary
• Ewing, Lin
• Faulconbridge, Lucy
• Foreyt, John
• Gaussoin, Sarah A
• Gregg, Edward W
• Hazuda, Helen P
• Hill, James O
• Horton, Edward S
• Hubbard, Van S
• Jakicic, John M
• Jeffery, Robert W
• Johnson, Karen C
• Kahn, Steven E
• Knowler, William C
• Lang, Wei
• Lewis, Cora E
• Montez, Maria G
• Murillo, Anne
• Nathan, David M
• Patricio, Jennifer
• Peters, Anne
• Pi-Sunyer, Xavier
• Pownall, Henry
• Rejeski, W Jack
• Rosenthal, Renate H
• Ruelas, Valerie
• Toledo, Katie
• Van Dorsten, Brent
• Vitolins, Mara
• Williamson, Donald
• Wing, Rina R
• Yanovski, Susan Z
• Zhang, Ping

Titel

Impact of Intensive Lifestyle Intervention on Depression and Health-Related Quality of Life in Type 2 Diabetes: The Look AHEAD Trial

Ist Teil von

• Diabetes care, 2014-06, Vol.37 (6), p.1544-1553

Ort / Verlag

Alexandria, VA: American Diabetes Association

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We examined the effects of an intensive lifestyle intervention (ILI), compared with a diabetes support and education (DSE) control intervention, on long-term changes in depression symptoms, antidepressant medication (ADM) use, and health-related quality of life (HRQoL) in overweight/obese individuals with type 2 diabetes. Look AHEAD was a multisite randomized controlled trial of 5,145 overweight/obese participants assigned to ILI (designed to produce weight loss) or DSE and followed for a median of 9.6 years. The Beck Depression Inventory (BDI) was administered at baseline, annually at years 1-4, and again at year 8. Mean BDI scores and incidence of BDI scores ≥10, indicative of likely mild or greater depression, were examined. Annually through year 10, participants reported their ADM use and completed the Medical Outcomes Study Short Form 36 (SF-36) questionnaire, which yields physical component summary (PCS) and mental component summary (MCS) scores. ILI significantly reduced the incidence of mild or greater depression symptoms (BDI scores ≥10) compared with DSE (hazard ratio [HR] = 0.85; 95% CI 0.75-0.97; P = 0.0145). Although SF-36 PCS scores worsened over time in both groups, ILI participants reported better physical function than DSE throughout the first 8 years (all P values <0.01). There were no significant differences between treatment arms in the proportion of participants who used ADMs or in SF-36 MCS scores. ILI for overweight/obese patients with type 2 diabetes may reduce the risk of developing clinically significant symptoms of depression and preserve physical HRQoL. These findings should be considered when evaluating the potential benefits of ILIs.