Details

Autor(en) / Beteiligte

• Keith, John M
• Apodaca, Rich
• Tichenor, Mark
• Xiao, Wei
• Jones, William
• Pierce, Joan
• Seierstad, Mark
• Palmer, James
• Webb, Michael
• Karbarz, Mark
• Scott, Brian
• Wilson, Sandy
• Luo, Lin
• Wennerholm, Michelle
• Chang, Leon
• Brown, Sean
• Rizzolio, Michele
• Rynberg, Raymond
• Chaplan, Sandra
• Breitenbucher, J. Guy

Titel

Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate

Ist Teil von

• ACS medicinal chemistry letters, 2012-10, Vol.3 (10), p.823-827

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2012

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey. The elevation of the levels of these lipids in the plasma of monkeys suggests that FAAH-2 may not play a significant role in regulating plasma levels of fatty acid ethanolamides in primates.