Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Ergebnis 6 von 17

Details

Autor(en) / Beteiligte
Titel
A genome-wide association study of attempted suicide
Ist Teil von
  • Molecular psychiatry, 2012-04, Vol.17 (4), p.433-444
Ort / Verlag
London: Nature Publishing Group UK
Erscheinungsjahr
2012
Quelle
MEDLINE
Beschreibungen/Notizen
  • The heritable component to attempted and completed suicide is partly related to psychiatric disorders and also partly independent of them. Although attempted suicide linkage regions have been identified on 2p11-12 and 6q25-26, there are likely many more such loci, the discovery of which will require a much higher resolution approach, such as the genome-wide association study (GWAS). With this in mind, we conducted an attempted suicide GWAS that compared the single-nucleotide polymorphism (SNP) genotypes of 1201 bipolar (BP) subjects with a history of suicide attempts to the genotypes of 1497 BP subjects without a history of suicide attempts. In all, 2507 SNPs with evidence for association at P <0.001 were identified. These associated SNPs were subsequently tested for association in a large and independent BP sample set. None of these SNPs were significantly associated in the replication sample after correcting for multiple testing, but the combined analysis of the two sample sets produced an association signal on 2p25 (rs300774) at the threshold of genome-wide significance ( P =5.07 × 10 −8 ). The associated SNPs on 2p25 fall in a large linkage disequilibrium block containing the ACP1 ( acid phosphatase 1 ) gene, a gene whose expression is significantly elevated in BP subjects who have completed suicide. Furthermore, the ACP1 protein is a tyrosine phosphatase that influences Wnt signaling, a pathway regulated by lithium, making ACP1 a functional candidate for involvement in the phenotype. Larger GWAS sample sets will be required to confirm the signal on 2p25 and to identify additional genetic risk factors increasing susceptibility for attempted suicide.
Sprache
Englisch
Identifikatoren
ISSN: 1359-4184
eISSN: 1476-5578
DOI: 10.1038/mp.2011.4
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4021719
Format
Schlagworte
Acid phosphatase, Adult and adolescent clinical studies, Alcoholism, Behavioral Sciences, Biological and medical sciences, Biological Psychology, Bipolar disorder, Bipolar Disorder - genetics, Bipolar Disorder - psychology, Brain - metabolism, Case-Control Studies, Emotional disorders, Epidemiology, Female, Gene polymorphism, Genes, Genetic aspects, Genetic Predisposition to Disease - genetics, Genome-wide association studies, Genome-Wide Association Study - methods, Genome-Wide Association Study - statistics & numerical data, Genomes, Genomics, Genotype, Health aspects, Humans, Linkage disequilibrium, Lithium, Male, Medical sciences, Medicine, Medicine & Public Health, Mental disorders, Mental health, Mood disorders, Neuropharmacology, Neurosciences, original-article, Pharmacology. Drug treatments, Pharmacotherapy, Phenotypes, Phosphatase, Polymorphism, Single Nucleotide, Protein Tyrosine Phosphatases - genetics, Protein Tyrosine Phosphatases - metabolism, Protein-tyrosine-phosphatase, Proto-Oncogene Proteins - genetics, Proto-Oncogene Proteins - metabolism, Psychiatry, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease), Psychological aspects, Psychology. Psychoanalysis. Psychiatry, Psychopathology. Psychiatry, Psychopharmacology, Risk factors, Single-nucleotide polymorphism, Suicidal behavior, Suicide, Suicide, Attempted - psychology, Suicides & suicide attempts, Wnt protein

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX