Details

Autor(en) / Beteiligte

• Kim, Taeshin
• Do, Minh-Ha T.
• Lawson, Mark A.

Titel

Translational control of gene expression in the gonadotrope

Ist Teil von

• Molecular and cellular endocrinology, 2014-03, Vol.385 (1-2), p.78-87

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• •GnRH acutely activates translation and gonadotropin synthesis.•GNRH activates cap-dependent translation and the unfolded protein response.•Gonadotropin and other mRNAs are targets of RNA-binding proteins in gonadotropes.•Cell and physiological homeostasis are monitored by translational control mechanisms. The study of gene expression in gonadotropes has largely focused on the variety of mechanisms regulating transcription of the gonadotropin genes and ancillary factors that contribute to the overall phenotype and function of these cells in reproduction. However, there are aspects of the response to GNRH signaling that are not readily explained by changes at the level of transcription. As our understanding of regulation at the level of mRNA translation has increased, it has become evident that GNRH receptor signaling engages multiple aspects of translational regulation. This includes activation of cap-dependent translation initiation, translational pausing caused by the unfolded protein response and RNA binding protein interaction. Gonadotropin mRNAs and the mRNAs of other factors that control the transcriptional and signaling responses to GNRH have been identified as targets of regulation at the level of translation. In this review we examine the impact of translational control of the expression of gonadotropin genes and other genes relevant to GNRH-mediated control of gonadotrope function.