Details

Autor(en) / Beteiligte

• Du, Qinglin
• Xie, Jianping
• Kim, Ha-Jeong
• Ma, Xiaojing

Titel

Type I interferon： the mediator of bacterial infection-induced necroptosis

Ist Teil von

• Cellular & molecular immunology, 2013-01, Vol.10 (1), p.4-6

Ort / Verlag

China: Nature Publishing Group

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• COMMENTARY Innate immune responses are essential for the host to fight against invading microbes. Innate immune receptors or pattern recog- nition receptors recognize conserved microbial molecules and trigger innate immune res- ponses. Pattern recognition receptors such as Toll-like receptors primarily signal through the adaptor MyD88 to activate NF-~B, while other Toll-like receptors signal v/a TRIF to activate IRF-3 resulting in the expression of type I interferons （IFNs）.a Type I IFNs play a crucial role in antiviral immune responses but are also important for the host response against bac- terial infection.2 Paradoxically.