Details

Autor(en) / Beteiligte

• Yu, De-gang
• Ding, Hui-feng
• Mao, Yuan-qing
• Liu, Ming
• Yu, Bo
• Zhao, Xin
• Wang, Xiao-qing
• Li, Yang
• Liu, Guang-wang
• Nie, Shao-bo
• Liu, Shen
• Zhu, Zhen-an

Titel

Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model

Ist Teil von

• Acta pharmacologica Sinica, 2013-03, Vol.34 (3), p.393-402

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Aim： To investigate whether strontium ranelate （SR）, a new antiosteoporotic agent, could attenuate cartilage degeneration and sub- chondral bone remodeling in osteoarthritis （OA）. Methods： Medial meniscal tear （MMT） operation was performed in adult SD rats to induce OA. SR （625 or 1800 mg·kg^-1·d^-1） was administered via gavage for 3 or 6 weeks. After the animals were sacrificed, articular cartilage degeneration was evaluated using toluidine blue 0 staining, SOX9 immunohistochemistry and TUNEL assay. The changes in microarchitecture indices and tissue mineral density （TMD）, chemical composition （mineral-to-collagen ratio）, and intrinsic mechanical properties of the subchondral bones were measured using micro-CT scanning, confocal Raman microspectroscopy and nanoindentation testing, respectively. Results： The high-dose SR significantly attenuated cartilage matrix and chondrocyte loss at 6 weeks, and decreased chondrocyte apop- tosis, improved the expression of SOX9, a critical transcription factor responsible for the expression of anabolic genes type II collagen and aggrecan, at both 3 and 6 weeks. Meanwhile, the high-dose SR also significantly attenuated the subchondral bone remodeling at both 3 and 6 weeks, as shown by the improved microarchitecture indices, TMD, mineral-to-collagen ratio and intrinsic mechanical prop- erties. In contrast, the low-dose SR did not significantly change all the detection indices of cartilage and bone at both 3 and 6 weeks. Conclusion： The high-dose SR treatment can reduce articular cartilage degeneration and subchondral bone remodeling in the rat MMT model of OA.