Details

Autor(en) / Beteiligte

• de Blank, P
• Cole, K
• Kersun, L
• Green, A
• Wilkes, J J
• Belasco, J
• Bagatell, R
• Bailey, L C
• Fisher, M J

Titel

fdg-pet in two cases of neurofibromatosis type 1 and atypical malignancies

Ist Teil von

• Current oncology (Toronto), 2014-04, Vol.21 (2), p.e345-348

Ort / Verlag

Canada: Multimed Inc

Erscheinungsjahr

2014

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Patients with neurofibromatosis type 1 (nf1) are at increased risk for both benign and malignant tumours, and distinguishing the malignant potential of an individual tumour is a common clinical problem in these patients. Here, we review two cases of uncommon malignancies (Hodgkin lymphoma and mediastinal germ-cell tumour) in patients with nf1. Although (18)F-fluorodeoxyglucose positron-emission tomography (fdg-pet) has been used to differentiate benign neurofibromas from malignant peripheral nerve sheath tumours, fdg-pet characteristics for more rare tumours have been poorly described in children with nf1. Here, we report the role of pet imaging in clinical decision-making in each case. In nf1, fdg-pet might be useful in the clinical management of unusual tumour presentations and might help to provide information about the malignant potential of uncommon tumours.