Details

Autor(en) / Beteiligte

• Cockrell, Adam S
• Peck, Kayla M
• Yount, Boyd L
• Agnihothram, Sudhakar S
• Scobey, Trevor
• Curnes, Nicole R
• Baric, Ralph S
• Heise, Mark T
• Lyles, D. S.

Titel

Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection

Ist Teil von

• Journal of virology, 2014-05, Vol.88 (9), p.5195-5199

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Human dipeptidyl peptidase 4 (hDPP4) was recently identified as the receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) infection, suggesting that other mammalian DPP4 orthologs may also support infection. We demonstrate that mouse DPP4 cannot support MERS-CoV infection. However, employing mouse DPP4 as a scaffold, we identified two critical amino acids (A288L and T330R) that regulate species specificity in the mouse. This knowledge can support the rational design of a mouse-adapted MERS-CoV for rapid assessment of therapeutics.