World journal of gastroenterology : WJG, 2014-04, Vol.20 (14), p.3960-3966
2014
Details
- Autor(en) / Beteiligte
- Titel
- New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer
- Ist Teil von
- World journal of gastroenterology : WJG, 2014-04, Vol.20 (14), p.3960-3966
- Ort / Verlag
- United States: Baishideng Publishing Group Co., Limited
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Gastric cancer is one of the most frequent cancers,and it ranks the third most common cancer in China.The most recently caudal-related homeobox transcription factor 2(CDX2)is expressed in a large number of human gastrointestinal cancers.In addition,gastric epithelial cell mutations in CDX2 result in tumor promotion,which is characterized by cellular drug resistance and a high proclivity for developing cancer.A series of publications over the past years suggests a mechanism by which CDX2 overexpression results in multidrug resistance.CDX2 appears to forward control regenerating Ⅳand the multidrug resistance 1 expression signaling pathway for regulation of cell drug resistance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1007-9327eISSN: 2219-2840DOI: 10.3748/wjg.v20.i14.3960Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3983451
- Format
- –
- Schlagworte
- Apoptosis, Caudal-related, CDX2 Transcription Factor, Cell Line, Tumor, Cell Nucleus - metabolism, Drug Resistance, Multiple, Drug Resistance, Neoplasm, factor, Gas, Gene Expression Regulation, Neoplastic, homeobox, Homeodomain Proteins - genetics, Humans, Intestines - pathology, Mutation, Oncogenes, Signal Transduction, Stomach Neoplasms - genetics, Topic Highlight, transcription, Treatment Outcome