Details

Autor(en) / Beteiligte

• Parsa, Afshin
• Kao, W.H. Linda
• Xie, Dawei
• Astor, Brad C
• Li, Man
• Hsu, Chi-yuan
• Feldman, Harold I
• Parekh, Rulan S
• Kusek, John W
• Greene, Tom H
• Fink, Jeffrey C
• Anderson, Amanda H
• Choi, Michael J
• Wright, Jackson T
• Lash, James P
• Freedman, Barry I
• Ojo, Akinlolu
• Winkler, Cheryl A
• Raj, Dominic S
• Kopp, Jeffrey B
• He, Jiang
• Jensvold, Nancy G
• Tao, Kaixiang
• Lipkowitz, Michael S
• Appel, Lawrence J

Titel

APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease

Ist Teil von

• The New England journal of medicine, 2013-12, Vol.369 (23), p.2183-2196

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study, APOL1 variants were associated with an increased risk of progression of chronic kidney disease in black patients, as compared with white patients, regardless of the cause of kidney disease or diabetes status. In the United States, black patients have approximately twice the risk of end-stage renal disease observed among white patients, after accounting for differences in socioeconomic and clinical risk factors. 1 – 4 This increased risk occurs despite a similar prevalence in earlier stages of chronic kidney disease 5 – 8 in the two racial groups, which suggests that kidney function declines more rapidly after the onset of chronic kidney disease in black patients. However, there is little direct evidence in support of this hypothesis. 9 – 13 The identification of factors that mediate differences in the progression of chronic kidney disease between black patients and white . . .