Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6158), p.591-591
2013
Details
- Autor(en) / Beteiligte
- Titel
- Circadian Clock NAD⁺ Cycle Drives Mitochondrial Oxidative Metabolism in Mice
- Ist Teil von
- Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6158), p.591-591
- Ort / Verlag
- United States: American Association for the Advancement of Science
- Erscheinungsjahr
- 2013
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found that the clock transcription feedback loop produces cycles of nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate production, and mitochondrial respiration through modulation of mitochondrial protein acetylation to synchronize oxidative metabolic pathways with the 24-hour fasting and feeding cycle. Circadian control of the activity of the NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms in the acetylation and activity of oxidative enzymes and respiration in isolated mitochondria, and NAD(+) supplementation restored protein deacetylation and enhanced oxygen consumption in circadian mutant mice. Thus, circadian control of NAD(+) bioavailability modulates mitochondrial oxidative function and organismal metabolism across the daily cycles of fasting and feeding.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1243417Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3963134
- Format
- –
- Schlagworte
- Acetylation, Animals, ARNTL Transcription Factors - genetics, ARNTL Transcription Factors - metabolism, Biological clocks, Biosynthesis, Cell cycle, Circadian Clocks - genetics, Circadian Clocks - physiology, Circadian rhythm, Clocks, Encoding, Energy Metabolism, Enzymes, Fasting, Gene expression regulation, Genes, Lipid Metabolism, Lipids, Liver, Liver - metabolism, Metabolism, Mice, Mice, Knockout, Mitochondria, Mitochondria, Liver - metabolism, NAD - metabolism, Organisms, Oscillation, Oxidation, Oxidation-Reduction, Oxygen Consumption, RESEARCH ARTICLE SUMMARY, Rodents, Sirtuin 3 - genetics, Sirtuin 3 - metabolism