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Autor(en) / Beteiligte
Titel
PD-1HIGH Follicular CD4 T Helper Cell Subsets Residing in Lymph Node Germinal Centers Correlate with B Cell Maturation and IgG Production in Rhesus Macaques
Ist Teil von
  • Frontiers in immunology, 2014-03, Vol.5
Ort / Verlag
Frontiers Media S.A
Erscheinungsjahr
2014
Link zum Volltext
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
  • CD4+ T follicular helper (TFH) cells guide development and maturation of B cells and are crucial for effective antibody responses. Here we found rhesus macaque TFH cells, defined as CXCR5+CD4 T cells, contain two major populations: PD-1(INT) and PD-1(HIGH) cells. Of these, PD-1(HIGH)CD4+ T cells highly co-express ICOS but little CCR7, and reside in lymph node germinal centers (GCs), but not in blood. These cells secrete IL-21 and express transcriptional factor Bcl-6 at higher levels than CXCR5+PD-1(INT)CD4+ T cells. In addition, the frequency of PD-1(HIGH)CD4+ T cells is low in lymph nodes of newborns, but increases with age. Levels of PD-1(HIGH)CD4+ T cells correlate with mature B cells in lymph nodes, and PD-1 blockade in PD-1(HIGH)CD4+ T and B cell co-cultures significantly inhibits IgG production. In summary, PD-1(HIGH)CD4+ T cells residing in GC represent a specific TFH subset that contributes to maturation of B cells and IgG production.
Sprache
Englisch
Identifikatoren
ISSN: 1664-3224
eISSN: 1664-3224
DOI: 10.3389/fimmu.2014.00085
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3958750

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