Molecular neurobiology, 2014-02, Vol.49 (1), p.590-600
2014
Details
- Autor(en) / Beteiligte
- Titel
- Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics
- Ist Teil von
- Molecular neurobiology, 2014-02, Vol.49 (1), p.590-600
- Ort / Verlag
- Boston: Springer US
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- Exosomes have emerged as prominent mediators of neurodegenerative diseases where they have been shown to carry disease particles such as beta amyloid and prions from their cells of origin to other cells. Their simple structure and ability to cross the blood–brain barrier allow great opportunity to design a “makeup” with drugs and genetic elements, such as siRNA or miRNA, and use them as delivery vehicles for neurotherapeutics. Their role in neuroprotection is evident by the fact that they are involved in the regeneration of peripheral nerves and repair of neuronal injuries. This review is focused on the role of exosomes in mediating neurodegeneration and neuroprotection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0893-7648eISSN: 1559-1182DOI: 10.1007/s12035-013-8544-1Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3951279
- Format
- –
- Schlagworte
- Animals, Biological Transport - drug effects, Biological Transport - physiology, Biomedical and Life Sciences, Biomedicine, Blood-brain barrier, Cell Biology, Drug delivery systems, Drug Delivery Systems - trends, Drug therapy, Exosomes - metabolism, Genetic Therapy - trends, Humans, MicroRNAs - administration & dosage, MicroRNAs - metabolism, Neurobiology, Neurodegeneration, Neurodegenerative Diseases - metabolism, Neurodegenerative Diseases - prevention & control, Neurology, Neuroprotective Agents - administration & dosage, Neuroprotective Agents - metabolism, Neurosciences, RNA, Small Interfering - administration & dosage, RNA, Small Interfering - metabolism